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KMID : 0377519860110010059
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Chung-Ang Journal of Medicine
1986 Volume.11 No. 1 p.59 ~ p.65
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Studies on the Carcinoembryonic Antigen and the Secretory Component in the Adenocarcinama of Stomach and Colon
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Abstract
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To observe the correlation between the carcinoembryonic antigen and the secretory component (SC} with their morphologic differentiation in the gastrointestinal carcinoma, immunohistochemical studies were carried out. The study consisted of gastric adenocarcinoma(16 cases), colonic adenocarcinoma(15 cases) and adenomatous polyp of colon(12 cases).
The results were as follows:
1. Poorly differentiated adenocarcinoma of stomach and colon shows more marked CEA-pos tMty in the cytoplasm and less marked activity along the luminal border than those of well differentiated adenocarcinoma.
2. Adenomatous polyp and hvperplastic glands near the carcinoma showed similar weak CEA positivity. The metaolastic goblet cells in stomach showed no CEA positivity.
3. SC positivity in adenocarcinoma of stomach and colon was less than CEA positivity of them, and the strongest positivity of SC in normal mucosa of colon was demonstrable.
Adenomatous polyp of colon and the hvperplastic glands near the carcinoma showed weak SC positivity. The metaplastic goblet cells in stomach showed no SC positivity.
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